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Parameters of Thromboelastography in Healthy Newborns

Rachel M. Edwards MBA, MT(ASCP), Bindi Jayendra Naik-Mathuria MD, Andre Nicholas Gay, Oluyinka O. Olutoye MBChB, PhD, Jun Teruya MD, DSc
DOI: http://dx.doi.org/10.1309/LABNMY41RUD099J2 99-102 First published online: 1 July 2008

Abstract

Thromboelastography (TEG) aids in monitoring a patient’s global hemostatic system by measuring the rate of clot formation, clot strength, and stability. The usefulness of TEG in pediatric settings, especially with neonates, is limited owing to a lack of neonatal reference values. In this study, neonatal TEG reference intervals were developed and results correlated with other coagulation test parameters. Samples were from women who delivered a neonate after at least 34 weeks of gestation in normal pregnancies. From the recovered placenta, cord blood from the umbilical vein or artery was collected within 30 minutes after delivery and tested. Neonatal TEG reaction time (time clot formation begins), clot firmness (shear elastic modulus strength), and platelet function analysis closure times were significantly lower than those in adult ranges (P < .001). When compared with the values for children, TEG reaction time, angle, coagulation index, clot firmness value, and clot kinetics (time from clot formation to time amplitude reaches 20 mm) were significantly different (P < .001) among neonates. TEG can be used to interpret the data for newborns by using reference values obtained in the present study.

Key Words:
  • TEG
  • Thromboelastography
  • Neonates
  • Reference range
  • Pediatric