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Primary Diffuse Large B-Cell Lymphoma of Bone Displays Preferential Rearrangements of the c-MYC or BCL2 Gene

Francisco Pignataro Lima MD, Marina Bousquet PhD, Anne Gomez-Brouchet MD, PhD, Geisilene Russano de Paiva MD, Eliane Maria Ingrid Amstalden MD, Fernando Augusto Soares MD, Nicole Dastugue MD, Jose Vassallo MD, Pierre Broussetx MD, PhD
DOI: http://dx.doi.org/10.1309/CMPGPYTMFRM6RVQR 723-726 First published online: 1 May 2008


We selected a series of 63 primary diffuse large B-cell lymphomas (DLBCLs) of bone collected in tissue microarrays from centers in France and Brazil. These cases were classified according to the expression of antigens associated with germinal center (GC; n = 42) or non-GC (n = 21) stages of B-cell differentiation. By fluorescence in situ hybridization, we found a substantial number of cases with a rearrangement of BCL2 (9/32) and c-MYC (n = 3), whereas the PAX5, BCL6, BCL1/cyclin D1, and ALK genes were in germline configuration. It is interesting that 1 case, with a GC phenotype, showed dual BCL2 and c-MYC rearrangement. The majority of the cases with rearrangements were of the GC phenotype. These results, associated with the lack of BCL6 rearrangement, suggest that bone DLBCL represents a specific group within extranodal B-cell lymphomas.

Key Words:
  • BCL2
  • c-MYC
  • Fluorescence in situ hybridization
  • FISH
  • Bone
  • B-cell lymphoma