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Usefulness of S100P in Diagnosis of Adenocarcinoma of Pancreas on Fine-Needle Aspiration Biopsy Specimens

Hongbing Deng MD, PhD, Jianhui Shi MD, PhD, Myra Wilkerson MD, Steven Meschter MD, William Dupree MD, Fan Lin MD, PhD
DOI: http://dx.doi.org/10.1309/5D76NDE81LE8G545 81-88 First published online: 1 January 2008


Even though the cytologic criteria for pancreatic ductal adenocarcinoma (PDA) on fine-needle aspiration biopsy (FNAB) specimens have been well defined, a diagnostic challenge is still present. We immunohistochemically evaluated the diagnostic value of S100P on cell-block and/or smear preparations in 58 cases of FNAB specimens of the pancreas. The 58 cases were divided into 4 groups: 1, 32 cases of PDA; 2, 6 cases with an atypical or “suspicious” diagnosis; 3, 14 cases of benign or reactive ductal epithelium; and 4, 6 cases of endocrine tumor. Positive immunoreactivity for S100P was observed in all cases in groups 1 and 2, whereas only 1 of 14 cases in group 3 was positive for S100P. All cases in group 4 were negative for S100P. S100P is a sensitive and specific marker for the detection of PDA on FNAB specimens on cell-block and smear preparations.

Key Words:
  • S100P
  • Pancreas
  • Adenocarcinoma
  • Fine-needle aspiration biopsy