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The Use of Fine Needle Aspiration Cytology for the Distinction of Pancreatic Mucinous Neoplasia

Edward B. Stelow MD, Vanessa M. Shami MD, Todd E. Abbott MD, Michelle Kahaleh MD, Reid B. Adams MD, Todd W. Bauer MD, Steven M. Debol MD, PhD, James M. Abraham MD, Shawn Mallery MD, Maria Luisa Policarpio-Nicolas MD
DOI: http://dx.doi.org/10.1309/Y16QCXE3YGMXX19Q 67-74 First published online: 1 January 2008


Cytology frequently has some role in preoperatively distinguishing pancreatic mucus-producing neoplasia (intraductal papillary mucinous neoplasms [IPMNs] and mucinous cystic neoplasms [MCNs]) from other pancreatic cysts. We evaluated all cytologic specimens at our institutions from resected pancreatic cystic lesions for lesional extracellular and cellular material. Lesional extracellular material was identified in 32 of 38 of the cytologic samples from cystic pancreatic mucus-producing neoplasms (28 of 31 IPMNs and 4 of 7 MCNs). Lesional cellular material was seen in 22 of 38 cases (17 of 31 IPMNs and 5 of 7 MCNs). Lesional material was more commonly identified in higher grade and invasive lesions. Lesional extracellular material was seen in 3 of 14 samples of other pancreatic cysts, and lesional cellular material was seen in 6 of 14 cases.

Key Words:
  • Endoscopic ultrasound
  • Fine-needle aspiration
  • Intraductal papillary mucinous neoplasm
  • Lymphoepithelial cyst
  • Mucinous cystic neoplasm
  • Pancreas
  • Pancreatic endocrine tumor
  • Pseudocyst