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Expression of HLA-G Is Associated With Prognosis in Esophageal Squamous Cell Carcinoma

Shang-mian Yie PhD, Hong Yang MD, Shang-rong Ye MD, Ke Li MD, Dan-dan Dong MD, Xin-mei Lin
DOI: http://dx.doi.org/10.1309/JNCW1QLDFB6AM9WE 1002-1009 First published online: 1 December 2007


The detection of HLA-G expression might serve as a clinical marker in the diagnosis or prediction of clinical outcomes for certain types of carcinoma. The aim of this study was to determine whether the detection of HLA-G has any important clinical applications for patients with esophageal squamous cell carcinoma (ESCC) by using immunohistochemical methods. We observed that the HLA-G protein was expressed in 90.9% (110/121) of the primary sites of ESCC but not in the normal esophageal tissues. The expression of HLA-G in the tumors was significantly correlated with histologic grade, depth of invasion, nodal status, host immune response, and clinical stage of disease. Patients with positive HLA-G expression had a significantly worse prognosis. In multivariate analysis, HLA-G was an independent prognostic factor. Our results indicate that expression of HLA-G is a characteristic feature of ESCC and suggest that immunostaining by anti–HLA-G antibodies may be a potentially useful prognostic indicator.

Key Words:
  • HLA-G
  • Esophageal squamous cell carcinoma
  • Immunohistochemistry
  • Prognosis