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Expression of GLUT1 in Primary Renal Tumors
Morphologic and Biologic Implications

Ayhan Ozcan MD, Steven S. Shen MD, PhD, Qihui “Jim” Zhai MD, Luan D. Truong MD
DOI: http://dx.doi.org/10.1309/HV6NJVRQKK4QHM9F 245-254 First published online: 1 August 2007

Abstract

This study aimed to assess whether glucose transporter 1 (GLUT1) is useful in prognostication or differential diagnosis of renal tumors. GLUT1 immunostain for 228 renal tumors showed a membranous or cytoplasmic pattern. The membranous pattern was seen in 86.2% of 145 clear cell renal cell carcinomas (RCCs) and 100% of 11 transitional cell carcinomas (TCCs) but in no oncocytomas, other subtypes of RCC, or sarcomatoid areas of RCCs. The cytoplasmic pattern was seen in 55.2% of 145 clear cell RCCs, 38% of papillary RCCs (11/29), 13% of chromophobe RCCs (2/16), 22% of oncocytomas (5/23), and 82% of TCCs (9/11). Western blot showed a markedly increased GLUT1 protein content in clear cell RCCs compared with a low level in papillary RCCs and normal kidney specimens. GLUT1 expression in clear cell RCC was not significantly correlated with patient survival, tumor grade, or tumor stage. GLUT1 may be a novel target for immunotherapy and a useful marker in the differential diagnosis and classification of renal tumors.

Key Words:
  • GLUT1
  • Renal neoplasm
  • Transitional cell carcinoma
  • Tissue microarray
  • Immunohistochemistry
  • Western blot