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Mature T-Cell Leukemias Including T-Prolymphocytic Leukemia, Adult T-Cell Leukemia/Lymphoma, and Sézary Syndrome

Kathryn Foucar MD
DOI: http://dx.doi.org/10.1309/KWJYBCCGTB90B6AE 496-510 First published online: 1 April 2007


The 2005 Society for Hematopathology/European Association for Haematopathology Workshop Session 1 was devoted to case presentations with discussions of 3 types of mature T-cell leukemias—T-cell prolymphocytic leukemia, adult T-cell leukemia/lymphoma, and Sézary syndrome. These 3 disorders are clonal proliferations of postthymic αβ T cells that are often characterized by systemic manifestations and a leukemic blood picture. The application of clinical, morphologic, immunophenotypic, and genetic studies to the assessment and characterization of these 3 disorders is presented, along with specific diagnostic recommendations and differential diagnostic considerations.

Key Words:
  • Mature T cell
  • Prolymphocytic
  • Adult T-cell leukemia
  • Sézary syndrome