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Expression of the B Cell–Associated Transcription Factors PAX5, OCT-2, and BOB.1 in Acute Myeloid Leukemia
Associations With B-Cell Antigen Expression and Myelomonocytic Maturation

Sarah E. Gibson MD, Henry Y. Dong MD, PhD, Anjali S. Advani MD, Eric D. Hsi MD
DOI: http://dx.doi.org/10.1309/UJUL60UPUP3YJE93 916-924 First published online: 1 December 2006


The aberrant expression of the B-cell transcription factor PAX5 has been described in a subset of acute myeloid leukemia (AML) with t(8;21)(q22;q22) in association with B-cell antigen expression. However, the expression of other B cell–associated transcription factors, particularly OCT-2 and its B cell–specific coactivator BOB.1, has not been described in AML. In this study, expression of PAX5, OCT-2 and BOB.1 was evaluated by immunohistochemical staining of bone marrow samples from 83 cases of AML. The expression patterns were correlated with t(8;21)(q22;q22), B cell–associated antigen expression, and AML subtype. We confirmed the expression of PAX5 in AML with t(8;21)(q22;q22), but also demonstrated its expression in cases that express B-cell antigens but lack this translocation. Although OCT-2 and BOB.1 were not associated with PAX5 expression, we report expression of OCT-2 in AML with myelomonocytic/monocytic maturation and BOB.1 in normal hematopoietic elements.

Key Words:
  • Acute myeloid leukemia
  • AML
  • PAX5
  • OCT-2
  • BOB.1