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Steroid Hormone Receptor Expression in Nasopharyngeal Angiofibromas
Consistent Expression of Estrogen Receptor β

Anthony G. Montag MD, Maria Tretiakova MD, PhD, Mary Richardson MD, DDS
DOI: http://dx.doi.org/10.1309/W5CM3A3NH7P4F5P2 832-837 First published online: 1 June 2006


Nasopharyngeal angiofibroma is an uncommon tumor arising in adolescent males, suggesting that the tumor may be hormonally responsive. Previous studies have found androgen receptor (AR) expression but variable expression of estrogen receptor (ER). The recently described β receptor for estrogen has not been analyzed in angiofibroma. We analyzed 13 cases of nasal angiofibroma by immunohistochemical analysis for the presence of ARs, progesterone receptors (PR), and ER-α and ER-β. All 13 cases were positive for ER-β in stromal pericytic and endothelial cells, and 12 of 13 stained strongly. Five cases were positive for AR in stromal cells, most staining weakly, and with no staining in endothelial or pericytic cells. None of the cases displayed staining for ER-α or PR. The findings confirm that nasopharyngeal angiofibromas express ER and suggest that new modulators of ER-β activity may provide an alternative therapy for these lesions.

Key Words:
  • Estrogen receptor β
  • Androgen receptor
  • Progesterone receptor
  • Angiofibroma