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Acute Myeloid Leukemia With Pseudo–Chédiak-Higashi Anomaly Exhibits a Specific Immunophenotype With CD2 Expression

Hong Chang PhD, MD, FRCPC, Qi Long Yi PhD
DOI: http://dx.doi.org/10.1309/93VFM8CY06KE6FD6 791-794 First published online: 1 May 2006


Acute myeloid leukemia (AML) with pseudo–Chédiak-Higashi (PCH) anomaly is a rare morphologic entity. We characterized 5 cases by multiparameter flow cytometry and found that in all cases, the blasts aberrantly expressed CD2, a pan–T cell–associated marker, in addition to their myeloid-associated markers. In contrast, CD2 was expressed in only 25 (17.9%) of 140 cases of newly diagnosed AML without PCH anomaly. CD2 expression correlated strongly with AML with PCH anomaly (P < .01), suggesting a link between a specific immunophenotypic marker, CD2, and AML with PCH anomaly.

Key Words:
  • CD2
  • Pseudo-Chèdiak-Higashi anomaly
  • Acute myeloid leukemia
  • AML