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Multilocular Cystic Renal Cell Carcinoma
A Report of 45 Cases of a Kidney Tumor of Low Malignant Potential

Sueli Suzigan MD, Antonio López-Beltrán MD, PhD, Rodolfo Montironi MD, FRCPath, Ricardo Drut MD, Ana Romero MD, Tomayoshi Hayashi MD, Ana L.C. Gentili MD, Paulo S.P. Fonseca MD, Ines deTorres MD, Athanase Billis MD, Lucia C. Japp MD, Enrico Bollito MD, Ferran Algaba MD, Maria J. Requena-Tapias MD
DOI: http://dx.doi.org/10.1309/AH6FC77PYR2V6YAY 217-222 First published online: 1 February 2006


The 2004 World Health Organization (WHO) classification of kidney tumors recognizes multilocular cystic renal cell carcinoma (MCRCC) as a rare variant of clear cell renal cell carcinoma with a good prognosis. Available information on its clinical significance is limited. The study cohort included 45 MCRCC cases classified according to 2004 WHO criteria obtained through a multi-institutional international search. Most patients had unilateral MCRCC with no side predominance that was found incidentally; 62% were men, but women had tumors at an earlier age (P = .385). MCRCC occurred slightly more often in men than in women (1.7:1). At diagnosis, 82% of patients had stage T1 and 16%, stage T2; 1 patient had stage T3. The Fuhrman grade was 1 (62%) or 2 (38%), with smaller tumors (≤4 cm) most likely Fuhrman grade 1 (P = .911). All 45 patients were alive with no evidence of disease at mean follow-up of 66.1 months, confirming an extremely good prognosis after surgery and a 5-year disease-specific survival rate of 100%. To rename this tumor as multilocular cystic renal cell neoplasm of low malignant potential might help urologists approach the patients conservatively.

Key Words:
  • Cystic renal cell carcinoma
  • Multilocular cystic carcinoma
  • Clear cell renal cell carcinoma
  • Low-grade cystic carcinoma