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Immunohistochemical Staining for Claudin-1 Can Help Distinguish Meningiomas From Histologic Mimics

Hejin P. Hahn MD, PhD, Elizabeth A. Bundock MD, PhD, Jason L. Hornick MD, PhD
DOI: http://dx.doi.org/10.1309/G659FVVBMG7U4RPQ 203-208 First published online: 1 February 2006


The histologic distinction between meningiomas and other tumors of the central nervous system occasionally can be difficult. Claudin-1 is a tight junction–associated protein recently shown to be expressed in anaplastic meningiomas. The purpose of this study was to determine whether immunohistochemical staining for claudin-1 could help distinguish meningiomas from histologic mimics, compared with commonly used markers. Tissue sections from 10 meningothelial meningiomas, 20 fibrous meningiomas, 10 atypical meningiomas, 7 solitary fibrous tumors of the meninges, 5 meningeal hemangiopericytomas, and 7 vestibular schwannomas were stained immunohistochemically for claudin-1, epithelial membrane antigen, S-100 protein, CD34, and glial fibrillary acidic protein. In total, 21 (53%) of 40 meningiomas were immunoreactive for claudin-1, whereas none of the other tumors were positive. In contrast, there was considerable overlap in the distribution of the other antibodies evaluated. Claudin-1 seems to be a specific marker for meningiomas in this context. Although its sensitivity is relatively low, claudin-1 may be helpful in a panel of immunostains to distinguish meningiomas from histologic mimics.

Key Words:
  • Immunohistochemistry
  • Claudin
  • Tight junctions
  • Meningioma
  • Schwannoma
  • Solitary fibrous tumor
  • Hemangiopericytoma
  • Soft tissue tumors