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Overexpression of Decoy Receptor 3 in Precancerous Lesions and Adenocarcinoma of the Esophagus

Huixiang Li MD, PhD, Lurong Zhang MD, PhD, Hong Lou MD, Ivan Ding MD, Sunghee Kim PhD, Luping Wang MD, Jiaoti Huang MD, PhD, P. Anthony Di Sant’Agnese MD, Jun-Yi Lei MD, PhD
DOI: http://dx.doi.org/10.1309/XK594E4B5WU82QR6 282-287 First published online: 1 August 2005


Overexpression of decoy receptor (DcR) 3 protein, a recently discovered member of the tumor necrosis factor receptor superfamily, was examined in 40 esophagogastrectomy specimens containing areas of Barrett esophagus (n = 27), low-grade dysplasia (n = 27), high-grade dysplasia or carcinoma in situ (n = 22), and esophageal adenocarcinoma (EAC; n = 28) with immunohistochemical analysis. The results revealed significantly more overexpression of DcR3 in high-grade dysplasia or carcinoma in situ and EAC than in benign esophageal mucosa (both P < .0001), Barrett esophagus (both P < .001), and low-grade dysplasia (P < .01 and P = .033, respectively). Low-grade dysplasia also showed significant overexpression of DcR3 compared with benign esophagus (P < .05) but not with Barrett esophagus (P > .05). DcR3 overexpression seems to negatively correlate with the grade of EAC. Our results suggest that overexpression of DcR3 protein might aid in the diagnosis of high-grade dysplasia or carcinoma in situ and EAC and also might serve as a potential therapeutic target.

Key Words:
  • Decoy receptor 3
  • Barrett esophagus
  • Esophageal cancer
  • Immunohistochemistry