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Blastic NK-Cell Lymphomas (Agranular CD4+CD56+ Hematodermic Neoplasms)
A Review

Tony Petrella MD, Martine Bagot MD, Rein Willemze MD, Marie Beylot-Barry MD, PhD, Béatrice Vergier MD, PhD, Michèle Delaunay MD, Chris J.L.M. Meijer MD, Philippe Courville MD, Pascal Joly MD, Florent Grange MD, PhD, Anne De Muret MD, Laurent Machet MD, Anne Dompmartin MD, Jacques Bosq MD, Anne Durlach MD, Philippe Bernard MD, Sophie Dalac MD, Pierre Dechelotte MD, Michel D’Incan MD, Janine Wechsler MD, Michael A. Teitell MD, PhD
DOI: http://dx.doi.org/10.1309/GJWNPD8HU5MAJ837 662-675 First published online: 1 May 2005


Blastic natural killer (NK) cell lymphoma (also termed CD4+CD56+ hematodermic neoplasm) is a recently described entity, with the first case reported in 1994. It was suggested initially that the disease originates from NK cells. Since 1994, single cases and a few small series have been published. In this review, data from the literature and a series of 30 cases from the French and Dutch study groups on cutaneous lymphomas are discussed. The major clinical, histopathologic, and phenotypic aspects of the disease and diagnostic criteria and data suggesting a plasmacytoid dendritic cell origin for the tumor cells are provided.

Key Words:
  • CD4
  • CD56
  • Blastic NK cell