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Hyalinizing Trabecular Adenoma of the Thyroid Gland
Identification Through MIB-1 Staining of Fine-Needle Aspiration Biopsy Smears

Mary B. Casey MD, Thomas J. Sebo MD, PhD, J. Aidan Carney MD, PhD
DOI: http://dx.doi.org/10.1309/5KJU9LV8LLA6CL76 506-510 First published online: 1 October 2004


Smears of fine-needle aspiration (FNA) biopsy specimens of 24 histologically proven and MIB-1–positive hyalinizing trabecular adenomas stained with Papanicolaou or Diff-Quik were stripped from the original slides, transferred to charged slides, destained, and restained with MIB-1. Positive immunoreactivity with MIB-1 in a peripheral cytoplasmic pattern was present in 17 specimens, no immunoreactivity was seen in 4 specimens, and equivocal staining was seen in 3 specimens. Papanicolaou-stained smears of papillary thyroid carcinoma, medullary thyroid carcinoma, thyroid follicular neoplasm, and Hürthle cell adenoma (5 specimens each) were treated similarly. None of the control cases stained with MIB-1 had the peripheral cytoplasmic pattern. Hyalinizing trabecular adenoma can be distinguished reliably from other thyroid neoplasms by MIB-1 staining of destained cells from FNA biopsy specimens.

Key Words:
  • Fine-needle aspiration biopsy
  • Hyalinizing trabecular adenoma
  • Medullary thyroid carcinoma
  • MIB-1 immunostaining
  • Papillary thyroid carcinoma