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Acute Myeloid Leukemia With t(6;9)(p23;q34) Is Associated With Dysplasia and a High Frequency of flt3 Gene Mutations

Mauricio P. Oyarzo MD, Pei Lin MD, Armand Glassman MD, Carlos E. Bueso-Ramos MD, PhD, Rajyalakshmi Luthra PhD, L. Jeffrey Medeiros MD
DOI: http://dx.doi.org/10.1309/5DGB59KQA527PD47 348-358 First published online: 1 September 2004

Abstract

We report 12 cases of t(6;9)(p23;q34)-positive acute myeloid leukemia (AML), all classified using the criteria of the World Health Organization classification. There were 10 women and 2 men with a median age of 51 years (range, 20-76 years). Dysplasia was present in all cases (9 previously untreated), and basophilia was present in 6 (50%). Immunophenotypic studies showed that the blasts were positive for CD9, CD13, CD33, CD38, CD117, and HLA-DR in all cases assessed. CD34 was positive in 11 (92%) of 12, and terminal deoxynucleotidyl transferase was positive in 7 (64%) of 11 cases. The t(6;9) was the only cytogenetic abnormality detected in 7 cases (58%), and 5 cases had additional chromosomal abnormalities. Of 8 cases assessed, 7 (88%) had flt3 gene mutations. We conclude that t(6;9)-positive AML cases have distinctive morphologic features, an immunophenotype suggesting origin from an early hematopoietic progenitor cell, and a high frequency of flt3 gene mutations.

Key Words:
  • Acute myeloid leukemia
  • t(6;9)(p23;q34)
  • dek-can
  • Immunophenotype
  • flt3