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Clinicopathologic Analysis of 22 Cases of Subcutaneous Panniculitis-Like CD56− or CD56+ Lymphoma and Review of 44 Other Reported Cases

Morishige Takeshita MD, Shuhei Imayama MD, Yumi Oshiro MD, Kenji Kurihara MD, Sumika Okamoto MD, Yasumasa Matsuki MD, Yutaka Nakashima MD, Takashi Okamura MD, Motoaki Shiratsuchi MD, Toru Hayashi MD, Masahiro Kikuchi MD
DOI: http://dx.doi.org/10.1309/TYRGT196N2APLLR9 408-416 First published online: 1 March 2004

Abstract

In 22 histologic cases of subcutaneous panniculitis-like lymphoma, we studied the clinicopathologic differences between CD56– and CD56+ cases (11 each). CD56– cases had skin ulcers (1 [9%]); tumor invasion in the superficial dermis (1 [9%]); erythrophagocytosis (10 [91%]); and medium-sized (11 [100%]), CD8+ (10 [91%]), T-cell receptor (TcR)β F1+ (10 [91%]), and CD95 (Fas)– tumor cells. CD56+ cases had skin ulcers (9 [82%]); tumor invasion in the superficial dermis (8 [73%]); erythrophagocytosis (1 [9%]); and pleomorphic large (10 [91%]), CD8+ (2/10 [20%]), TcRβ F1+ (3/10 [30%]), and CD95 (Fas)+ (7/10 [70%]) tumor cells. These 7 factors were significantly different between groups (P < .01). Median survival rates were 96 and 12 months for the CD56– and CD56+ groups, respectively. Age younger than 40 years, no skin ulcers, no tumor invasion in the superficial dermis, and CD8+, TcRβF1+, CD95 (Fas)–, and CD56– tumor cells were significantly better prognostic factors (P < .01). The CD56– and CD56+ groups showed different tumor cell characteristics, clinicopathologic findings, and prognosis. In the CD56+ group, 1 was γ/δ T-cell phenotype, 3 were α/β T-cell, and 6 were TcRβ F1– and γ/δ– NK/T-cell, and 3 NK/T-cell cases had nuclear signals of Epstein-Barr virus–encoded RNA. Cases of CD56+ T- and NK/T-cell lymphoma had similar clinicopathologic findings and prognosis.

Key Words:
  • Panniculitis
  • T-cell and NK/T-cell lymphoma
  • CD56