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MIB-1 and DNA Topoisomerase IIα Could Be Helpful for Predicting Long-Term Survival of Patients With Glioblastoma

Donald Ming-Tak Ho MD, FRCPC, FCAP, Chih-Yi Hsu MD, MHA, Ling-Tan Ting MSc, Hung Chiang MD
DOI: http://dx.doi.org/10.1309/UN4WV65UH94JEWUV 715-722 First published online: 1 May 2003

Abstract

Approximately 10% of patients with glioblastoma survive more than 2 years after diagnosis. Distinguishing these patients from those who died within 2 years of diagnosis is clinically significant. We studied the MIB-1 labeling index (LI) and DNA topoisomerase IIα LI of glioblastomas from 34 patients who lived for more than 2 years after diagnosis and of glioblastomas from 34 age- and sex-matched control patients who died within 2 years of diagnosis. The means of MIB-1 and topoisomerase IIα LIs of the group with a better outcome were lower. With 35 as the cutoff point for the MIB-1 LI and 26 as the cutoff point for the topoisomerase IIα LI, both MIB-1 and topoisomerase IIα LIs were related significantly to survival. Our study showed that both MIB-1 and topoisomerase IIα could help predict long-term survival of patients with glioblastomas. Multivariate analyses revealed that MIB-1 was a better prognostic marker than topoisomerase IIα.

Key Words:
  • Glioblastoma
  • MIB-1
  • Ki-67
  • DNA topoisomerase IIα