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Uterine Granulomas
Clinical and Pathologic Features

Mohammad O. Almoujahed MD, Laurence E. Briski MD, Michael Prysak PhD, MD, Leonard B. Johnson MD, Riad Khatib MD
DOI: http://dx.doi.org/10.1309/QFKL-WRWB-KYFE-KX2E 771-775 First published online: 1 May 2002


We retrospectively studied the clinical and pathologic features of uterine granulomas over a 10-year period. Granulomas were detected in 30 women, 22 to 81 years old, in the cervix (n = 12/1,090 cervical specimens; 1.1%) or uterine corpus (n = 18/12,000 uterine specimens; 0.15%). They were discovered during evaluation of abnormal bleeding, cytologic specimens, or other gynecologic conditions. None of the patients had constitutional symptoms. These granulomas were often focal (n = 25 [83%]), exhibiting features of foreign body–type (n = 17 [68%]); or they were diffuse (n = 5 [17%]), all with negative acid-fast bacilli or fungal stains and sometimes necrotizing (2 [40%]). Focal granulomas were highly associated with a preceding biopsy or surgery (22/25 vs 14/53 age-matched control subjects). Follow-up of 28 patients (median, 16 months) showed that 27 remained healthy; only 1 patient developed generalized lesions consistent with sarcoidosis 16 months later. Uterine granulomas are rare. They are either focal, related to previous biopsy or surgery, or diffuse, usually representing local reaction without an obvious cause. Association with infection or systemic granulomatous disorders is uncommon.

Key Words:
  • Granulomas
  • Cervix
  • Uterine