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Cytogenetic Findings in Lymphoplasmacytic Lymphoma /Waldenström Macroglobulinemia
Chromosomal Abnormalities Are Associated With the Polymorphous Subtype and an Aggressive Clinical Course

Adnan Mansoor MD, L. Jeffrey Medeiros MD, Donna M. Weber MD, Raymond Alexanian MD, Kimberly Hayes, Dan Jones MD, PhD, Raymond Lai MD, PhD, Armand Glassman MD, Carlos E. Bueso-Ramos MD, PhD
DOI: http://dx.doi.org/10.1309/6U88-357U-UKJ5-YPT3 543-549 First published online: 1 October 2001


We correlated bone marrow cytogenetic findings with morphologic and immunophenotypic data in 37 patients with lymphoplasmacytic lymphoma (LPL)/Waldenström macroglobulinemia (WM). Each LPL/WM case was classified as lymphoplasmacytoid (n = 18), lymphoplasmacytic (n = 10), or polymorphous (n = 9) using the Kiel criteria. Of 12 cases with chromosomal abnormalities, a single numeric abnormality was present in 4 and a complex karyotype in 8. The most common numeric abnormalities were +5 and –8 in 3 cases each; the most common structural abnormality was del(6q) in 6 cases. Cytogenetic abnormalities were significantly less common in the lymphoplasmacytic and lymphoplasmacytoid groups (5/28 [18%]) compared with the polymorphous group (7/9 [78%]). Clinical follow-up was available for 28 patients for a median of 36 months. Six (67%) of 9 patients with aneuploid tumors, including 4 with polymorphous subtype, subsequently had clinical progression or developed high-grade lymphoma. In contrast, 4 (21%) of 19 patients with diploid tumors, including 1 of polymorphous type, developed clinical progression or high-grade lymphoma. We conclude that abnormal cytogenetic findings in LPL/WM correlate with the polymorphous subtype and poor prognosis.

Key Words:
  • Lymphoplasmacytic lymphoma
  • Waldenström macroglobulinemia
  • Cytogenetics
  • Chromosomal abnormalities