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Reduced Number of CD1a+ Cells in Cutaneous B-Cell Lymphoma

Matthias Schmuth MD, Alexis Sidoroff MD, Barbara Danner, Gerda Topar MD, Norbert T. Sepp MD
DOI: http://dx.doi.org/10.1309/G828-D7YC-Y98R-QRR9 72-78 First published online: 1 July 2001

Abstract

Cutaneous B-cell lymphoma is difficult to distinguish from pseudolymphoma. The histologic pattern and monoclonal restriction (immunohistochemical analysis and molecular biology) are the criteria used for differentiating these entities. CD1a+ dendritic cells have been observed in the infiltrates of T-cell lymphoma, but the presence of these CD1a+ cells has not been compared in B-cell lymphoma and pseudolymphoma. We studied the presence of CD1a+ cells on frozen sections of 23 B-cell lymphomas, 13 pseudolymphomas, and 17 T-cell lymphomas by immunohistochemical analysis. We found abundant CD1a+ dendritic cells in only 1 (4%) of 23 B-cell lymphomas, whereas in 8 (62%) of 13 pseudo-lymphomas and 17 (100%) of 17 T-cell lymphomas, strong CD1a staining was present. Our study demonstrates a distinct pattern of CD1a staining in the infiltrates of B-cell lymphoma and pseudolymphoma that may be of value in the differential diagnosis of these skin disorders.

Key Words:
  • Antigen-presenting cells
  • CD1a
  • Cutaneous lymphoma
  • Immunohistochemistry