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Primary Endometrial T-Cell Lymphoma
A Case Report

Cheryl M. Kirk MD, R. Wendel Naumann MD, Christopher J. Hartmann MA, Charlotte A. Brown PhD, Peter M. Banks MD
DOI: http://dx.doi.org/10.1309/DN0L-F9P7-E263-6512 561-566 First published online: 1 April 2001


Primary lymphomas of the female genital tract are rare. Most involve the cervix rather than the uterine corpus. All of those previously reported have been B-cell lymphomas, with the exception of 1 case report of an endometrial T-cell lymphoma in a Japanese woman. We report the case of a white woman from the United States with a diffuse large cell lymphoma of the endometrium, characterized as a peripheral T-cell type on the basis of immunophenotypic and molecular probe studies. Staging evaluation revealed tumor limited to the endometrium (stage IE). The patient underwent a total abdominal hysterectomy, bilateral salpingo-oophorectomy, and lymph node dissection and received 6 cycles of combination chemotherapy, after which she remained free of disease at last follow-up of 36 months. Unusual features of this lymphoma case are discussed, with emphasis on differential diagnosis and speculation on histogenesis. This case illustrates that, while most peripheral T-cell lymphomas are widely disseminated at presentation, those limited to a single extranodal site may have a favorable outcome akin to that associated with high-grade extranodal B-cell lymphomas of early stage.

Key Words:
  • Endometrial lymphoma
  • Uterine lymphoma
  • T-cell lymphoma
  • Peripheral T-cell lymphoma
  • Female genital tract