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The (11;14)(q13;q32) Translocation in Multiple Myeloma
A Morphologic and Immunohistochemical Study

James D. Hoyer MD, Curtis A. Hanson MD, Rafael Fonseca MD, Philip R. Greipp MD, Gordon W. Dewald PhD, Paul J. Kurtin MD
DOI: http://dx.doi.org/10.1309/4W8E-8F4K-BHUP-UBE7 831-837 First published online: 1 June 2000

Abstract

We identified 24 cases of multiple myeloma with thet(11;14)(q13;q32). In 22 cases, the t(11;14)(q13;q32)was part of a complex karyotype, and in 2 cases it wasan isolated abnormality. All patients had clinical andlaboratory features consistent with multiple myeloma.The median degree of plasma cell involvement in thebone marrow was 60%, and in 10 cases, the plasmacells had a lymphoplasmacytoid appearance. Of the 24cases, 21 had intermediate or high proliferative ratesbased on labeling index studies. Immunohistochemicalstudies performed on all bone marrow biopsyspecimens showed strong cyclin D1 nuclear positivity in19 cases. There also was strong cyclin D1 nuclearpositivity found in 6 of 30 additional cases without thet(11;14)(q13;q32) demonstrated by routine cytogenetics.The t(11;14)(q13;q32) in multiple myelomaresults in overexpression of the cyclin D1 protein, whichcan be demonstrated by immunohistochemical stain.The cyclin D1 stain results in the additional cases ofmultiple myeloma suggest that the t(11;14)(q13;q32)may be more common than previously thought and maybe missed by routine cytogenetics, particularly if theproliferative rate is low.

Key Words:
  • t(11;14)(q13;q32)
  • Multiple myeloma
  • Cyclin D1
  • Immunohistochemistry