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Virus Infection in Patients With Histiocytic Necrotizing Lymphadenitis in Taiwan
Detection of Epstein-Barr Virus, Type I Human T-Cell Lymphotropic Virus, and Parvovirus B19

Chang-Fang Chiu MD, PhD, Kuan-Chih Chow PhD, Tze-Yi Lin MD, PhD, Ming-Hsui Tsai MD, Chi-Min Shih MD, Li-Mien Chen MD
DOI: http://dx.doi.org/10.1309/1A6Y-YCKP-5AVF-QTYR 774-781 First published online: 1 June 2000


The relationship of Epstein-Barr virus (EBV), type I human T-cell lymphotropic virus (HTLV-I), and parvovirus B19 to histiocytic necrotizing lymphadenitis was studied prospectively in 10 Taiwanese patients using materials obtained by fine-needle aspiration and lymph node biopsy. The presence of EBV was detected by in situ hybridization for EBV-encoded RNA expression. Immunocytochemistry was used to detect virus-encoded protein for EBV and parvovirus B19. DNA in situ hybridization and polymerase chain reaction were performed to determine the existence of HTLV-I provirus. Expressions of EBV-encoded RNA and Fas ligand were detected in all cases. Expression of EBV-encoded protein was identified in only 1 case. Neither HTLV-I nor parvovirus B19 was detected in any case.

Key Words:
  • Histiocytic necrotizing lymphadenitis
  • EBV
  • Epstein-Barr virus
  • HTLV-I
  • Human T-cell lymphotropic virus type I
  • Parvovirus B19
  • Fas ligand